Clinical précis: Lactobacillus plantarum 299v (TuZen)
in irritable bowel syndrome (IBS)
IIBS and the microbiome2
While the causes of IBS are still under investigation, researchers now accept that an imbalance in the gut’s microbial flora – the microbiome - is a contributing factor. Probiotics are a natural treatment option, and work by altering the ability of pathogenic bacteria to adhere to the bowel wall through several mechanisms of action:

  • Creating a physical barrier
  • Altering the epithelial surface glycosylation pattern
  • Increasing mucin production

Probiotics also secrete antimicrobial peptides and modulate the immune system.
L. plantarum 299v (TuZen): Demonstrated relief in as many as 9 out of 10 patients with IBS3
There are several probiotic products available to relieve the symptoms of IBS; the major difference between them is the strain(s) of active bacteria they contain. The probiotics in TuZen have undergone the highest standards of scrutiny available for natural health products.

Relief of abdominal pain and bloating.4
A study published in 2012 evaluated L. plantarum,4 one of the Lactobacillus spp. commonly found in healthy bowel mucosa.5 The authors of this randomized, double-blind, placebo-controlled trial of 214 patients with IBS concluded:

“ . . . L. plantarum 299v (DSM 9843) [TuZen] is a probiotic strain able to relieve IBS symptoms, particularly abdominal pain and bloating, in IBS patients fulfilling the Rome III criteria.”4

Study details


Decreased pain and flatulence.5
“The results of this study indicate that administration of Lactobacillus plantarum DSM 9843 [TuZen] with known probiotic properties decreases pain and flatulence in patients with IBS.”

Study details

Improvement in 95% of patients.3
“With regards to all IBS symptoms an improvement was noted in 95% of patients in the [TuZen] group vs 15% of patients in the placebo group (P<0.0001).”

Study details

The probiotics in TuZen have undergone the highest standards of scrutiny available for natural health products. TuZen bears Natural Product Number (NPN) 80019103.
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For more information,
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The World Health Organization defines a clinical trial as “any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes.”
An NPN indicates a product has been issued a product license by Health Canada, and appears in Health Canada’s Natural Health Products Database.